锂盐药物相互作用en

**✽ Nonsteroidal anti-inflammatory agents, including ibuprofen and selective COX-2 inhibitors (cyclooxygenase 2), can increase plasma lithium concentrations; add with caution to patients stabilized on lithium **

**✽ Diuretics, especially thiazides, can increase plasma lithium concentrations; add with caution to patients stabilized on lithium **

• Angiotensin-converting enzyme inhibitors can increase plasma lithium concentrations; add with caution to patients stabilized on lithium

• Metronidazole can lead to lithium toxicity through decreased renal clearance

• Acetazolamide, alkalizing agents, xanthine preparations, and urea may lower lithium plasma concentrations

• Methyldopa, carbamazepine, and phenytoin may interact with lithium to increase its toxicity

• Use lithium cautiously with calcium channel blockers, which may also increase lithium toxicity

• Use of lithium with an SSRI may raise risk of dizziness, confusion, diarrhea, agitation, tremor

• Some patients taking haloperidol and lithium have developed an encephalopathic syndrome similar to neuroleptic malignant syndrome

• Lithium may prolong effects of neuromuscular blocking agents

• No likely pharmacokinetic interactions of lithium with mood-stabilizing anticonvulsants or atypical antipsychotics

Stahl, S. (2020). Stahl’s Essential Psychopharmacology: Prescriber’s Guide. In Prescriber’s Guide: Stahl’s Essential Psychopharmacology (p. III). Cambridge: Cambridge University Press.